Nurovo completed a controlled preclinical study with more than 40 healthy participants in collaboration with Dr. Nanshu Lu and The University of Texas at Austin. The study investigated how EEG-recorded neural activity changes across multiple experimentally induced pain conditions and how those changes relate to participants’ reported pain.
Participants underwent three controlled pain modalities, including a cold pressor test, pressure-based stimulation, and electrical stimulation using TENS, while EEG brain activity was recorded throughout testing. Pain ratings and physiological measurements, including blood pressure, were collected alongside the EEG recordings to characterize neural responses across different pain intensities and stimulus types.
Recordings across baseline, stimulation, and recovery periods allowed researchers to examine changes in EEG activity associated with the onset, intensity, and resolution of experimentally induced pain.
Nurovo is preparing a multi-site perioperative clinical study with collaborators at Yale School of Medicine, including Dr. Robert Chow and Dr. Sudhir Kadian, to evaluate EEG-based pain measurement across approximately 1,000 patient observations across two hospitals, extending the research from controlled experimental pain into real-world clinical care.
Patients will undergo repeated EEG recordings and pain assessments throughout the perioperative period, including measurements before and after procedures and around administration of analgesic medications. This longitudinal design will allow neural activity to be compared with changes in patient-reported pain over time and following pain treatment.
Conducted across two hospital settings, the study is designed to evaluate neural pain signatures across a substantially larger and more clinically diverse population while examining how EEG measurements change with pain progression, procedural intervention, recovery, and analgesic response.